It's a brand new year and a brand new decade, but that's not going to stop me from finding decaying old programs from the early 1990s that nobody has played in years!
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Presenting "Dr. Rudy", a DOS game initially released in 1991 and is quite clearly a Dr. Mario clone. NES emulation through DOS wouldn't really kick-off until 1997 and it would take even longer for other Nintendo systems to be supported, so for many years this was one of the only ways you could play Dr. Mario on your IBM compatible PC.
It's notable for two reasons... or maybe three. One, it's yet another example of a very early Mario fangame... sort of (nineteen years old and still beating modern attempts!), two it'll run on even the most insanely underpowered PCs and three because I still claim
Dr. Hello is worth caring about and this shares a similar concept.